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Preservatives

Preservatives by Frequency of Use in Cosmetic Formulations

The use of preservatives for cosmetic purposes is regulated in the EU by the Commission Directive 2007/17/EC of 22 March 2007, amending Council Directive 76/768/EEC, concerning cosmetic products, for the purposes of adapting Annexes III and VI.

http://eur-lex.europa.eu/Notice.do?mode=dbl&lang=en&ihmlang=en&lng1=en,de&lng2=bg,cs,da,de,el,en,es,et,fi,fr,hu,it,lt,lv,nl,pl,pt,ro,sk,sl,sv,&val=446113:cs&page=#top

The Annex VI of the Council Directive 76/768/EEC can be found under

http://borealischem.com/pdf/Annex6%20Parts1-2PreservativesList.pdf

In the US preservatives are registered by the FDA.

In Japan the use of preservatives in cosmetics is regulated by the “Standards for Cosmetics” (Ministry of Health and Welfare Notification No.331 of 2000), Appendix 3, see also

http://www.mhlw.go.jp/english/topics/cosmetics/index.html

The frequency of use of preservatives in the US in 2005 is given in the following table.

PreservativeFrequency of use (2005)
Methylparaben7866
Propylparaben6260
Butylparaben2784
Ethylparaben2310
Phenoxyethanol2227
Imidazolidinyl urea2036
Sodium sulfite1306
Resorcinol1176
DMDM hydantoin1062
Diazolidinyl urea737
Methylchloroisothiazolinone/methylisothiazolinone 818699
Sorbic acid/potassium sorbate639
Benzoic acid/Sodium benzoate582
Dehydroacetic acid/Sodium dehydroacetate559
Quaternium-15515
Isobutylparaben507
Benzyl alcohol502
Triclosan484
Boric acid/sodium borate353
Iodopropynyl butylcarbamate195
2-Bromo-2-nitropropane-1,3-diol187
Sodium methylparaben160
Salicylic acid140
Methyldibromo glutaronitrile115
Formaldehyde113
Benzalkonium chloride82
Chlorhexidine digluconate68
Sodium bisulfite62
Chlorphenesin58
Hexamidine isethionate47
Isopropylparaben47
Chloroxylenol44
Chloroacetamide36
Sodium hydroxymethylglycinate35
5-Bromo-5-nitro-1,3-dioxane34
Benzethonium chloride32
Sodium propylparaben30
Methenamine28
o-Phenylphenol/Sodium-o-phenylphenol28
Phenethyl alcohol28
Grapefruit Seed Extract23
Triclocarban22
Paraformaldehyde21
Glutaraldehyde (Glutaral)19
Polymethoxy bicyclic oxazolidine19
Chlorhexidine dihydrochloride18
o-Cymen-5-ol18
Thymol13
Piroctone olamine12
Dichlorobenzyl alcohol11
Chlorhexidine acetate9
Climbazole9
Formic acid and salts7
Hinokitiol7
Domiphen bromide6
Phenoxyisopropanol6
Dichlorophene5
p-Chloro-m-cresol5
Phenyl mercuric acetate5
Thiomersal5
Undecylenic acid and salts4
Dimethyloxazolidine2
Polyaminopropyl biguanide2
Benzylparaben1
Chlorhexidine1
7- Ethylbicyclooxazolidine1
Total formulations reported22228

Reference: D. C. Steinberg, 2005 Preservatives use: Frequency reports and registration, Cosmetic and Toiletries magazine 121(7), 65-69 (2006).